What is a VDR?

VDR is a Virtual Data Room that provides secure, reliable access to confidential documents for business transactions. VDRs are a great tool for performing due diligence in mergers and acquisitions. They also assist businesses organize important documents and share them with investors and other stakeholders. VDRs can also be used to store and manage contracts, invoices, and other legal documents like estate planning and litigation.

Members should examine their current procedures and the equipment installed on their vessels with VDR/SVR installed. It is also advisable to take the opportunity to consider changing and upgrading those that are outdated or that are not in compliance with minimum safety requirements.

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the expression of proteins that are involved in a myriad of physiological processes.

The VDR is located in cells of glial origin, and subsets of them that form part of the brain. In the primary hippocampal cells of rats, VDR immunoreactivity was detected in the oligodendrocytes. The VDR is also found in human neuroblastoma as well as astrocytes. The treatment of leukemia cells from HL-60 by 1,25(OH2)2D3 led to monocyte-like differentiation and higher VDR levels. This effect was inhibited by inhibitors of the PI3-K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.

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